The Effects of Reserpine on Depression
Course Description: This course is based on material published in the Journal of Psychopharmacology and is available as an open-access article.
Reserpine is an effective antihypertensive drug, but its role in routine practice has declined such that it is rarely used. This is largely based on the assumption that reserpine causes depression. This assumption was a foundation for the original monoamine hypothesis of depression. However, there remains conflicting evidence as to whether reserpine causes depression and no systematic review of available evidence. We systematically reviewed the evidence on the effects of reserpine on depressive and related symptoms (e.g., anxiety, suicidal ideation). Electronic searches of MEDLINE, Embase, and PsycINFO were conducted to identify studies up to 14 February 2021. Studies of any methodological design involving reserpine-treated and reserpine-untreated conditions in any adult human population were included, and a narrative synthesis of findings was undertaken. The risk of bias (RoB) was examined using ROBINS-I. Of the 35 studies meeting inclusion criteria, 9 were randomized controlled trials. Eleven studies reported some depressogenic effects, 13 reported no effect, and 11 reported putative antidepressant effects. Studies identifying depressive effects were more likely to examine people without psychiatric disorders at baseline, while studies identifying a potential antidepressant effect tended to treat fewer participants for shorter durations at higher doses. Around one-third of studies conducted in people with psychiatric disorders showed beneficial effects on depression symptoms. 30/35 studies were at high RoB. Associations between reserpine and depression are inconsistent and limited by a lack of high-quality evidence. Due to reserpine’s apparently complex effects, we urge nuance rather than simplicity surrounding the monoamine hypothesis of depression.
This course on the relationship between reserpine and depression is designed for social workers, professional counselors, psychologists, nurses, and substance abuse counselors who do clinical work. In addition, this course is appropriate for intermediate and advanced level practitioners who wish to develop their knowledge of the relationship between reserpine and depression. The course material includes a literature review of research. It may also be useful for licensed clinicians who require continuing clinical education courses for license renewal.
The course is based on a journal article that includes research. It contains statistical analysis and data that some clinicians enjoy reading, and others do not. A significant benefit of reading research-based articles for continuing education is they provide practitioners with the latest findings in their field.
Authors: Strawbridge, Javed, Cave, Juahar, Yound
Learning Objectives: This course will provide the practitioner with detailed information regarding the relationship between reserpine and depression. Specifically, a professional will:
- Identify characteristics of reserpine and its proposed mechanism of provoking depression.
- Recognize primary and secondary outcomes of the relationship between reserpine and depression.
- Describe the putative antidepressant effects of reserpine.
Citation: Strawbridge, R., Javed, R. R., Cave, J., Jauhar, S., & Young, A. H. (2023). The effects of reserpine on depression: A systematic review. Journal of Psychopharmacology (Oxford, England), 37(3), 248–260. https://doi.org/10.1177/02698811221115762
This course content is based on a publication that has been peer-reviewed, the scientific standard for evaluating academic work. All studies and scientifically derived evidence have limitations that should be considered. If you have any questions about the accuracy or limitations of the content, please contact us at
support@ce-classes.com and we will get back to you.
This Ce-Classes.com course is approved for CE credit by:
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- The American Psychological Association (APA) Ce-Classes.com is approved by the American Psychological Association to sponsor continuing education for psychologists. Ce-Classes.com maintains responsibility for this program and its content.
- Association of Social Work Boards (ASWB) Ce-Classes.com, Provider #1142, is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program. Organizations, not individual courses, are approved as ACE providers. State and provincial regulatory boards have the final authority to determine whether an individual course may be accepted for continuing education credit. Ce-Classes.com maintains responsibility for this course. ACE provider approval Period: 1/5/2029
Social workers participating in this course will receive 1 Clinical continuing education clock hours.- The National Board for Certified Counselors (NBCC) Ce-Classes.com has been approved by NBCC as an Approved Continuing Education Provider, ACEP No. 6320. Programs that do not qualify for NBCC credit are clearly identified. Ce-Classes.com is solely responsible for all aspects of the programs.
- California Board of Behavioral Sciences. The California Board of Behavioral Sciences, BBS, recognizes relevant course work/training that has been approved by nationally recognized certifying bodies, such as APA, to satisfy renewal requirements.
- California Board of Registered Nursing. CEP 15647 Expires 11/30/2026.
- California Association of DUI Treatment Programs (CADTP) Provider Number 231
- California Consortium of Addiction Programs and Professionals (CCAPP) Provider Number OS-12-174-0627 Expires 6-2027
- Florida Board of Clinical Social Work, Marriage and Family Therapy and Mental Health Counseling Provider #852 BAP-Expires 3/31/2027
- Florida Board of Nursing (CE Provider #: 50-4896) Expires 10/31/2028 Do not send certificates to the Florida Board of Nursing. You must keep this certificate for 4 years.
- Florida Certification Board
- Alcohol and Drug Abuse Certification Board of Georgia (ADACBGA) Alcohol and Drug Abuse Certification Board of Georgia (ADACBGA) Provider number# 16-04-05-626
- Illinois – CE-Classes.com is a registered social work CE sponsor by the State of Illinois. License 159.001607 Expires 11/30/2027
- Massachusetts Authorization Number: 2948%2Fthe-effects-of-reserpine-on-depression-
- New York Mental Health Practitioners Board CE-Classes.com, Inc. is recognized by the New York State Education Departments State Board for Mental Health Practitioners as an approved provider of continuing education for licensed mental health counselors. #MHC-0260.
- New York Psychology Board CE-Classes.com, Inc. is recognized by the New York State Education Departments State Board for Psychology as an approved provider of continuing education for licensed psychologists #PSY-0211
- New York Social Work Board – Ce-Classes.com is recognized by the New York State Education
Department’s State Board for Social Work as an approved provider of
continuing education for licensed social workers #SW-0120.
- Ohio Counselor, Social Worker and Marriage and Family Therapist Board – Approval from a state licensing board for counselors, social workers, marriage and family therapists is accepted by the OH CSWMFTB.
- Oklahoma Board of Behavioral Health Licensure (LPCs, LMFTs and LBCs)
- South Carolina – CE-Classes.com is approved by the S.C. Board of Examiners for Licensure of Professional Counselors, Marriage & Family Therapist, Addiction Counselors, and Psycho-Educational Specialists (#4696).
- Texas Board of Marriage & Family Therapists CE-Classes.com meets the requirements for acceptable continuing education. Effective 1/1/24, at least half of the 30 hours must be obtained from a provider listed in 801.261(f). This course meets that requirement.
- Texas Board of Professional Counselors – CE-Classes.com meets the requirements for acceptable continuing education. Effective 1/1/24, at least half of the 30 hours must be obtained from a provider listed in 801.261(f). This course meets that requirement.
- Texas Board of Social Work Examiners – CE-Classes.com meets the requirements for acceptable continuing education. Effective 1/1/24, at least half of the 30 hours must be obtained from a provider listed in 801.261(f). This course meets that requirement.
